Cognitive functioning in children and adolescents with multiple sclerosis

To examine cognitive functioning in children with multiple sclerosis (MS). The authors
examined the neuropsychological profile of 37 children with a diagnosis of clinically definite MS and assessed the
associations between cognitive function and clinical features. Of 37 children and adolescents evaluated, 35%
demonstrated significant cognitive impairment. Cognitive functioning was strongly related to several clinical variables,
including current Expanded Disability Status Scale, total number of relapses, and total disease length. The consequences
of MS adversely affected academic functioning in over a third of the children. Cognitive deficits occur in
children with multiple sclerosis. Comprehensive treatment planning should involve recognition that they may require
academic accommodations for their education.