Cognitive Function in Patients with Dominant Hemisphere Glioma in Sina Hospital in 2018

Glioma is a kind of CNS tumor, originated from glial cells. CNS diseases can present with Sensory-Motor, Cognitive or psychological dysfunctions. Dysfunction in sensory-motor domain can be measured with standard physical examination and Para clinics, but evaluating dysfunction in cognitive and psychological domains are usually more complicated.

30 patients with dominant hemisphere gliomas, operated in Sina hospital were assessed in this study. They were undergone cognitive examination with Addenbrooke’s Cognitive Examination (ACE) pre operatively, post operatively and 3 and6 months after surgery.

Before Surgery, mean cognitive function mark before surgery was 74.2±16.78. Just post operatively mean cognitive function mark slightly <font>drop</font>ped to 64.17±18.2 but this <font>drop</font> wasn’t statistically meaningful. 3 months after surgery, patients’ cognitive function got better and reached 74±16.61 and 6 months after surgery, mean cognitive function mark in patients, reached 82.76±12.9. This improvement at 6 months after surgery in comparison to just post-operative status was statistically significant.

In pre-operative assessment, 83.3% of patients have some degrees of cognitive dysfunction. This makes cognitive dysfunction, a significant sign of gliomas. Although post operatively we observed a slight decline in cognitive function, but in 6 months, most patients significantly recovered.