Protective Effect of Aerobic Training along with Resveratrol on the Expression of some Atrophic Biomarkers of Cardiomyocytes in Diabetic rats

IntroductionThe aim of the present study was to examine the effect of aerobic training along with resveratrol on cardiac expression of FOXO3a and MuRF1 in diabetic male rats.Materials and MethodsForty Wistar male rats were randomly classified into Control-Normal (CN), Diabetes Mellitus (DM), Resveratrol-Diabetes Mellitus (RDM), Training-Diabetes Mellitus (TDM) and Training-Resveratrol-Diabetes Mellitus (TRDM) groups. Training groups have performed a running program on a motor-driven treadmill for eight weeks. Resveratrol (20 mg/kg) was injected into the RDM and TRDM groups. Forty-eight hours after the last training session, rats were sacrificed; hearts were excised and immediately frozen in liquid nitrogen and stored at -80 °C for measuring the indexes. Statistical analysis was performed using a one-way analysis of variance, and significance was accepted at p ≤ 0.05.ResultsThe results of this study showed a reduction in the expression of FOXO3a (p=0.0001) and MuRF1 (p=0.0001) cardiomyocytes in  the TDM group compared to the DM group. The expression of FOXO3a (p=0.045) and MuRF1 (p=0.037) in the RDM group was significantly decreased in comparison to the DM group. Also, the expression of FOXO3a (p=0.026) and MuRF1 (p=0.007) cardiomyocytes in the TRDM groups also had a significant decrease compared to the DM group.ConclusionOur findings show that an aerobic training with and without resveratrol maybe inhibits atrophic biomarkers of cardiomyocytes in diabetic male rats.