The prevalence of obesity and type2 diabetes are escalating at an alarming rate in many developed as well as developing countries. Irisin is a novel muscle and adipose derived chemokine that is, proteolytically processed from the product of the FNDC5 (fibronectin type ш domain containing 5) gene. The purpose of this study is to examine the effect of tow kind of training on irisin in sedentary obese women.
In this study 22 obese women (medium age: 37± 6 year, height: 1.55 ± 0.04 meter, BMI: 35 ± 0.29 kg/m2) were randomly assigned to two training groups Isocracy (resisting (n: 12) and concurrent (n: 11)). They attributed for three sessions a week for eight weeks. Before and after the period, the levels of irisin, fasting glucose, insulin and insulin resistance with HOMA-IR index and viscera ratio to body muscle were investigated. Finally, the data were analyzed using tow way ANOVA evaluated.
After 8 weeks exercise glucose in resistance groups and irisin in all groups had significant changes (P<0.05) but we did not find significant differences in fasting glucose, insulin, HOMA-IR and irisin between the groups (P>0.05).
In summery in this study there were no difference between groups of training. It can be hypothesis that the increase of irisin in obese people is one of the preventing ways against of obesity's side effects. Exercise could improve the signaling pathways and consume the fat accumulations, therefore at the end of exercise duration, irisin decreased.