The effects of 8 weeks aerobic training and intermittent hypoxia on lipid peroxidation and total antioxidant capacity in male Westar rats

Oxidative stress disrupts the redox balance and induces various diseases. The aim of this study is to investigate about the effects of 8 weeks aerobic training and intermittent hypoxia on lipid peroxidation and total antioxidant capacity in male Westar rats.

Forty male Wistar rats weighing 220+20 were randomly divided into four groups of: control (C), hypoxia (H), Hypoxia+ training (H+T) and training (T) groups, namely. Hypoxia group was exposed to chronic intermittent hypoxia. And the exercise group ran on a treadmill (22-26 meters per min) for 8 weeks, 5 session/ weeks. After the 8 weeks of the running, blood samples of the subjects were taken. Data were analyzed by using Anova and Tukey statistical tests at the significant level of P≤0.05.

The results showed that MDA index in the training group was significantly lower than the other groups (P= 0/001, F= 19 .634). But, no significant differences were observed between control group with hypoxia (P= 984.0), combination of (H) with (T) group (P =824.0), and (H+T) with (C) group (P= 997.0). Also, TAC capacity in the training group was significantly higher than the other groups (P= 0.001, F= 7.388). However, there was no significant difference observed between the control group with hypoxia (P= 0.368) and (H+T) with (C) group (P= 0.996), and the combination of (H+T) with (H) group (P= 0.837).

It seems that moderate intensity exercise training will lead to a redox balance compared with other stimuli and will prevent oxidative stress