The protective effects of quercetin against malathion- induced oxidative stress and myocardial damage in in Wistar male rats

The purpose of this study was to investigate the protective effects of quercetin on myocardial tissue damage in male Wistar rats during malathion poisoning.

This study was performed on seven groups of six male rats. After 24 hours of intraperitoneal injection of quercetin, Malathion or a combination of these drugs, the heart of the animals was separated, and tissue slice was prepared. After tissue homogenization, oxidative stress parameters were measured in this area.

Intraperitoneal injection of 200 mg/kg of malathion significantly induced lipid peroxidation (p<0.01) and oxidative stress (p<0.001) as well as necrosis and inflammation in myocardial tissue. However, intra-peritoneal injection of quercetin (50 mg/kg) reduced malathion-induced toxicity on lipid peroxidation (p<0.001), oxidative stress (p<0.05), as well as inflammation and myocardial tissue damage.

The results suggest that quercetin is able to improve myocardial tissue damage and restore the rate of oxidative stress in malathion-treated groups to normal levels.