The Sedation Effect of Midazolam-Fentanyl and Midazolam-Propofol Combination in Patients with Elective Upper Gastrointestinal Endoscopy in Ali-ebne Abitaleb Hospital, Zahedan, in 2018

Upper gastrointestinal endoscopy is a widely used method for the diagnosis and treatment of upper gastrointestinal diseases, but it is necessary to identify patients with less complicated drugs. The aim of this study was to compare the sedative effect of two medicinal compounds midazolam-fentanyl with midazolam-propofol in patients with upper gastrointestinal endoscopy .

This study was performed on 147 patients with upper gastrointestinal endoscopy (70 in midazolam-fentanyl group and 77 in midazolam-propofol group). Patients were randomly divided into two groups. The target drugs were prescribed and vital signs and sedation were recorded. Chi-square and Mann-Whitney tests were used to compare the data .

The results of the present study showed that the frequency of deeper sedation with higher satisfaction in the midazolam / propofol group was significantly higher than the midazolam / fentanyl group but on the other hand, the frequency of apnea in the midazolam / propofol group was more than the other group .

Given the prevalence of endoscopy in Iran and the need for safe sedation for patients with higher efficacy, it is suggested that midazolam / propofol combination be used for patient sedation and should not be used only in patients with poor prognosis for apnea. This method was used to sedate patients .