Investigating the relationship between IFN-γ levels in the maternal serum and neonatal cord blood in term and prolonged deliveries in Rafsanjan Niknafs Maternity in 2018

Cytokines play an important role in generating and maintaining acquired immunity responses duringpreterm, term, and prolonged pregnancy. It seems that IFN-g levels in the maternal serum and neonatal cord blood are associated with the type of delivery. Accordingly, this study aimed to investigate the cytokine IFN-g concentrations in the maternal serum and neonatal cord blood in term and prolonged deliveries.

This descriptive study was conducted on 125 cord blood specimens from neonates born through term and prolonged-pregnancy and the 122 serum samples from their mothers in Rafsanjan Niknafs Maternity in 2018. The IFN-g levels in the maternal serum and neonatal cord blood were measured by enzyme-linked immunosorbent assay (ELISA) and compared by the independent samples t-test.

The results revealed that IFN-g levels were not significantly different between prolonged-pregnancy mothers and their neonates compared with term mothers and their neonates, but a weak positive correlation was found between IFN-g in cord blood of term neonates and the age of the mothers (r = 0.240, p=0.05).

The results showed that IFN-g has not effect on prolonged-pregnancy