Effects of Training and Octopamine Supplementation on Expression of M1 and M2 Monocyte/Macrophage Surface Markers in White Adipose Tissue of Rats Poisoned with Deep-Fried Oil
Message:
Abstract:
Background

 It showed that the infiltration of macrophages into adipose tissue is the origin of inflammation. Despite the positive effect of training and octopamine on the inflammatory process and adipose tissue permeability to macrophages, the simultaneous effect of aerobic training (AT) and octopamine (O), as a lipolytic agent on macrophage permeability in a high-fat diet situation, is unclear.

Objectives

 This study aimed to investigate the effect of AT and O supplementation on CD86 and CD206 concentration in white adipose tissue of rats poisoned with deep-fried oil (DFO).

Methods

 A total of 30 male Wistar rats were divided into groups, including healthy control, DFO control, AT + DFO, O + DFO, and AT + O + DFO. During the four weeks the O groups received 81 μmol/kg octopamine for five days/week intraperitoneally, and AT groups performed training with moderate intensity (26 m/min). Forty-eight hours after the last intervention, the rats were anesthetized and subcutaneous adipose tissue was removed for CD86 and CD206 assays.

Results

 DFO significantly increased CD86 and reduced CD206; AT was able to reduce the CD86 increase, however, it had no effect on CD206; O significantly reduced CD86 and increased CD206; in addition, interaction of AT and O on CD86 was significant.

Conclusions

 Both AT and O can reduce the negative effect of deep-fried oil on macrophage permeability in adipose tissue.
 

Article Type:
Research/Original Article
Language:
English
Published:
Gene, Cell and Tissue, Volume:7 Issue:1, 2020
Page:
4
magiran.com/p2083841  
روش‌های دسترسی به متن این مطلب
اشتراک شخصی
در سایت عضو شوید و هزینه اشتراک یک‌ساله سایت به مبلغ 300,000ريال را پرداخت کنید. همزمان با برقراری دوره اشتراک بسته دانلود 100 مطلب نیز برای شما فعال خواهد شد!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی همه کاربران به متن مطالب خریداری نمایند!