The Study of Oxidative Stress-Dependent Changes Caused by Social Stress in Brain and Kidney Tissues

The effect of social stress on the occurrence of cardiovascular and mental diseases is obvious. In order to investigate the effect of these stresses on oxidative stress induction, and changes in the oxidant and antioxidant levels, the model for roommate change restriction and observation in the presence of curcuma longa antioxidant was designed A total of 60 Wister rats were kept under standard conditions of temperature, light, and water. In the under-stress groups, each rat was provided with one third of its common food. The roommate change stress and observation were applied to two groups of these rats. Two groups of rates were fed by the food contained curcuma longa. These rats kept under defined conditions for each group for 4 months i.e., roommate change, observation, curcuma longa; food restriction, observation, roommate change, curcuma longa; control; control, curcuma longa. After the rats' maintenance period was completed, they were anesthetized with ether and their kidney and brain tissues were homogenized. Each of the given factors i.e., malon-dialdehyde, glutathione, nitric oxide, cathepsin D and lipofuscin was measured in tissues. The malon-dialdehyde level increased significantly both in brain and kidney in under-stress group. The level of nitric oxide and glutathione increased in brain, but the activity of cathepsin D and lipofuscin accumulation remained unchanged. Also the amount of nitric oxide and glutathione remained the same. The brain is more sensitive to MDA formation, but the amount of glutathione and nitric oxide is higher. Thus social stress induced changes do not occur equally in kidney and brain tissues.