Thrombosis; the First Manifestation of Acute Promyelocytic Leukemia in an 8 –Year- Old Boy: A case report

Venous and arterial thrombosis is uncommon in children and usually occurs in cases with central venous catheter, immobility, heart disease, trauma, cancer, surgery, infection, dehydration, shock, obesity, nephrotic syndrome, antiphospholipid antibody syndrome and coagulation disorders. Here a case report of an 8-year-old boy is reported who was referred with pain in the legs for 2 months before admission, morning headache, and vomiting for 3 weeks and cyanosis of the first and second right toes a week before admition. In the initial laboratory tests, the patient had only normochromic, normocytic anemia. In color doppler ultrasonography and computed tomography angiography, thrombosisin the right popliteal artery was reported, which was extended to proximal posterior of right tibialis artery. The patient was treated with aspirin, but developed pulmonary thrombosis and pancytopenia during admission. Bone marrow aspiration confirmed promyelocytic leukemia. Patient expired prior to chemotherapy due to extensive intracerebral hemorrhage.