Risk factors of the efficacy of hepatitis B vaccine in health care workers

Conventional hepatitis B virus vaccination fails to achieve efficient protection in about 5%–10% of the world population. Different factors influence the immunogenicity of hepatitis B vaccine. This study aimed to evaluate these factors in health‑care workers.

This was a descriptive study which was implemented among 140 of medical and dental staff working as health‑care workers who were low responder after vaccination entered the study.

Age (>40 years), weight (body mass index >25), immunodeficiency diseases, (primary immune deficiency and immunosuppressant drugs), diabetes mellitus, and smoking were the important factors.

In the high‑risk group of hepatitis B disease, the risk factors of immunogenicity must be evaluated at vaccination and check titers of antibody after vaccination.