Molecular Mechanisms of Parkinson's Disease

Parkinson's disease is a common neurodegenerative disorder. In this disease, mitochondrial defects and oxidative stress lead to the enhancement of the free radicals and the death of dopamine neurons in the Sabstantia nigra. The clinical symptoms of this disease are including tremor, muscle stiffness, and inability to walk as well as cognition, memory and learning deficits. Aging increases the severity of Parkinson's disease.

Any therapeutic strategy which can modulate antioxidant homeostasis and neuroprotection may increase the life expectancy and quality of life of patients with Parkinson's disease.