The Effect of Pretreatment of Aerobic Training on Some of the Pulmonary Stress Indices against the Toxicity of Doxorubicin

The purpose of this study was to determine the effect of pretreatment of aerobic training on stress and inflammatory indices [heat shock protein-70 (HSP70), superoxide dismutase (SOD), malondialdehyde (MDA) and C-reactive protein (CRP)] induced by doxorubicin in lung tissue of aging male rats.

16 male rats were randomly divided into aging + doxorubicin (AD) and aging + doxorubicin + training (ADT) groups. The training group ran on a treadmill for three weeks at speeds of 15-17 m/minute for 25-39 minutes and five sessions a week. Subjects received doxorubicin (20 mg/kg) 24 hours after the last training session. The biopsy was taken 48 hours later. Data were analyzed using one-way ANOVA and Scheffe post hoc test via SPSS software.

Three weeks of the aerobic training only resulted in a significant increase of HSP70 and SOD, and decrease of MDA in the lung tissue in the training group compared to the control group.

Doing exercises before treatment with doxorubicin appear to be effective in elderly people, probably due to changes in the protective proteins of the cell in inhibiting or reducing oxidative damage.