The morphological & histopathological changes of placenta in pregnancies obtained by Intracytoplasmic sperm injection (ICSI)
Message:
Abstract:
Background

Growth of the fetus is directly related to the structure and function of the placenta, and the examination of the Placenta and umbilical cord provides us important information about what has happened to the fetus. Pregnancies induced by ART are more likely to develop pregnancy complications than other singleton pregnancies. The main cause of these undesirable pregnancy outcomes is uncertain, and perhaps morphological and histopathologic abnormalities of placenta in these types of pregnancies may be involved. Since the most common method of ART is the ICSI method, the aim of this study was to evaluate the histological changes of the placenta and umbilical cord in ICSI pregnancies.

Methods

In this study, 30 women who were pregnant with ICSI method and had no pregnancy complications were compared with 30 pregnant women with normal and non-complicated pregnancies. Morphology and histology of the placenta and umbilical cord were compared in two groups. For studying with optical microscopy, samples of the placenta were prepared from two groups were stained with H & E, PAS and trichrome, and compared with the optical microscope.

Results

There was no difference between the two groups in demographic variables. umbilical cord length, 1th and 5th minute Apgar score in two groups. The umbilical cord thickness (p = 0.01), and placental thickness (p = 0.02) was significantly higher in the study group. In the pathological study of placenta, it was revealed that in study group there are increased syncytial knot in staining with hematoxin and eosin, reducing of glycogen in PAS staining, and increasing the amount of fibrosis in trichrome staining compared with the control group.

Conclusion

The study of pathological changes in ICSI pregnancies compared with normal pregnancies showed that the prevalence of syncytial knots (Due to the accumulation of the nucleus of apoptotic cells in the placenta) is significantly higher.

Article Type:
Research/Original Article
Language:
Persian
Published:
Medical Journal of Tabriz University of Medical Science & Health Service, Volume:42 Issue: 1, 2020
Pages:
97 - 103
magiran.com/p2102108  
برخی از خدمات از جمله دانلود متن مقالات تنها به مشترکان مگیران ارایه می‌گردد. شما می‌توانید به یکی از روش‌های زیر مشترک شوید:
اشتراک شخصی
در سایت عضو شوید و هزینه اشتراک یک‌ساله سایت به مبلغ 400,000ريال را پرداخت کنید. همزمان با برقراری دوره اشتراک بسته دانلود 100 مطلب نیز برای شما فعال خواهد شد!
پرداخت با کارتهای اعتباری بین المللی از طریق PayPal امکانپذیر است.
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی همه کاربران به متن مطالب خریداری نمایند!
توجه!
  • دسترسی به متن مقالات این پایگاه در قالب ارایه خدمات کتابخانه دیجیتال و با دریافت حق عضویت صورت می‌گیرد و مگیران بهایی برای هر مقاله تعیین نکرده و وجهی بابت آن دریافت نمی‌کند.
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.