Lymphoma of base of The Tongue, Consideration to mycological examination along with immunohistochemistry: A Case report

Malignant Lymphoma of the Head & neck (oral cavity or buccal mucosa) is uncommon and of the tongue fewer. Commensal bacteria and fungi that may become pathogenic often colonize the oral cavity and cause severe problems in people with cancer and immunocompromised. We describe a 76-year-old man with a history of dysphagia and a bulk lesion from his base of the tongue that was diagnosed as diffuse B cell lymphoma. He was followed up with Doxorubicin, Rituximab, Vincristine sulfate and radiotherapy.  However, oral lymphoma of the tongue is very uncommon and it should be review in the differential assessment of numerous malignant lesions in this region. Due to weakened immune system and susceptible to infection in cancer patients, attention to opportunistic microorganisms, especially fungi that cause severe problems in cancer patients, can help them to choose better treatment. Fungal culture from new samples and genotyping of microorganisms along with Immunohistochemistry of biopsy can monitor treatment and clinical follow-up.