The impact of preinjury consumption of antithrombotic drugs on clinical outcomes of patients with moderate to severe traumatic brain injury
Message:
Article Type:
Research/Original Article (بدون رتبه معتبر)
Abstract:
Background & Aim

The main goal of the present study was to investigate the impact of preinjury intake of direct oral anticoagulants (DOACs), warfarin, and antiplatelet on clinical and radiological neuro-deterioration of patients with moderate to severe traumatic brain injury (TBI).

Materials & Methods

We investigated 224 consecutive patients more than 50 years old with moderate and severe TBI admitted to the Taleghani hospital, Kermanshah, Iran, between Jul 2014 and Jul 2019, retrospectively. Demographic, clinical, and laboratory data were retrospectively reviewed using the electronic medical records of all patients. Patients were categorized into four groups: nonuser patients, patients on platelet inhibitors, patients on warfarin and patients taking any DOACs. Clinical outcome was evaluated with the Glasgow Outcome Scale.

Results

95 patients (42.4%) received no anti thrombotic drugs before the trauma. However, 69 patients (30.8%) were receiving platelet inhibitors, 42 subjects (18.8%) were on the warfarin, and 18 cases (8.0%) were on the DOACs before their trauma. There were 41 cases (18.3%) with in-hospital mortality. Our results showed that, 108 patients (48.2%) had a favorable outcome and 116 ones (51.8%) had an unfavorable outcome. Patients on Warfarin and those were receiving DOACs were associated with higher mortality as well as a more unfavorable clinical outcome (p<0.005).

Conclusion

Preinjury use of DOACs and warfarin is associated with higher mortality and worse clinical outcome. However, preinjury antiplatelet therapy did not contribute to in-hospital mortality and poor clinical outcomes.

Language:
Persian
Published:
Scientific Journal of Nursing, Midwifery and Paramedical Faculty, Volume:5 Issue: 4, 2020
Pages:
94 to 104
magiran.com/p2103438  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!