Synthesis of 2-Amino-4hydroxy-1H-Pyrrole-3-Carbonitrile from Glycine Under Microwave Irradiation

Reaction of Glycin with Malononitrile afforded respective Pyrrole. Pyrrole is one of the heterocyclic compounds with very important biological activities. Heterocycles are extremely important because of their wide range of applications that goes from their use as pharmaceuticals and agrochemicals to dyestuffs and additives. In this view, it was proposed to synthesize pyrrole-3-carbonitrile derivative. An efficient one-step protocol has been developed to make new molecules of this family. An expeditious synthesis of derivatives pyrrole has been developed by reacting Malononitrile  and Glycine derivatives using a microwave. The structures of synthesized were assigned on the basis of IR and 1H NMR spectroscopy data