Different Polymorphisms of Vascular Endothelial Growth Factor Gene in Patients with Pre-Eclampsia among The Iranian Women Population

Pre-eclampsia (PE) is a pregnancy complication and one of the leading causes of maternal and neonatal morbidity and mortality in the world. PE is characterized by high blood pressure and signs of damage to another organ system, most often the liver and kidneys. Given the importance of mutation in the VEGF gene and its correlation with the incidence of pre-eclampsia, the relationship between polymorphisms rs922583280 ,rs3025040 and rs10434 of encoding gene VEGF with the incidence of pre-eclampsia in the population of Iranian women was studied in this research.

100 pregnant women with pre-eclampsia diagnosis and 50 healthy pregnant women for determination of genotypes rs922583280, rs3025040 and rs10434 were evaluated using the Sanger sequencing method.

There was no significant difference in the frequency of alleles of rs922583280 and rs3025040 polymorphisms between case and control groups (P>0.05), but the frequency of recessive allele G in rs10434 polymorphism was significantly higher in the case group than in the control group (Pvalue=0.014, case=24%, control=12%), while the frequency of the allele A in the control group was higher than that of the patient group (case=76%, control=88%) The frequency of AG genotype in the patient group was also higher than the control group and the frequency of AA genotypes in the control group was higher than that of the patient group (case=57%, control= 78).

The results of this study demonstrated that polymorphism rs10434 of the gene encoding VEGF has a significant difference among individuals of the control group and the patient group and can affect the incidence of pre-eclampsia among Iranian women.