Nanostructured lipid carriers (NLCs) are novel pharmaceutical formulations which arecomposed of physiological,biocompatible lipids,surfactants,co-surfactants. Over time,as a second generation lipid nanocarrier NLC has emerged as an alternative to first generationnanoparticles. This review article highlights the structure,composition,various formulationmethodologies,and characterization of NLCs which are prerequisites in formulating a stabledrug delivery system. NLCs hold an eminent potential in pharmaceuticals,cosmetics marketbecause of extensive beneficial effects like skin hydration,occlusion,enhanced bioavailability,and skin targeting. This article aims to evoke an interest in the current state of art NLC bydiscussing their promising assistance in topical drug delivery system. The key attributes of NLCthat make them a promising drug delivery system are ease of preparation,biocompatibility,thefeasibility of scale up,non-toxicity,improved drug loading,and stability.
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