Evaluation of Salivary Interleukin-6 Levels in Children with Mild and Severe Early Childhood Caries before and Three Months after Treatment
To evaluate and compare salivary IL6 level in children with early childhood caries, before and 3 months after treatment.Materials &
In this study totally 32 children aged 3 to 6 years (12 without any caries, 10 with mild caries: 1 < dmft < 4, 10 with severe caries: dmft > 5) were included. Salivary samples were taken from all children at least 1 hour after eating food. The group with severe ECC were treated as a full-mouth rehabilitation under general anesthesia. The group with mild ECC were treated in clinic. Group with no ECC followed with no treatment. 3 months after full-mouth rehabalitation, salivary samples gathered again. Data analysis was performed using Kolmogorov-Smirnov, Wilcoxon, Kruskal Wallis tests with SPSS version 22 software.
Baseline IL6 was higher in patients with severe ECC (p value = 0.007 and P = 0.001) but there was no statistically significant difference in baseline levels between first two groups. (p value = 0.059). After treatment only severe ECC group had statistically significant difference ofsalivary IL6 after treatment. (p value = 0.007).
Our findings show that salivary IL6 level could be a partial predictor of ECC lesions. Treatment in sever ECC caused statistically significant decrease in IL6 but IL6 change was not significantin mild group.
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