Evaluation of Salivary Interleukin-6 Levels in Children with Mild and Severe Early Childhood Caries before and Three Months after Treatment
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Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Introduction

To evaluate and compare salivary IL6 level in children with early childhood caries, before and 3 months after treatment.Materials &

Methods

In this study totally 32 children aged 3 to 6 years (12 without any caries, 10 with mild caries: 1 < dmft < 4, 10 with severe caries: dmft > 5) were included. Salivary samples were taken from all children at least 1 hour after eating food. The group with severe ECC were treated as a full-mouth rehabilitation under general anesthesia. The group with mild ECC were treated in clinic. Group with no ECC followed with no treatment. 3 months after full-mouth rehabalitation, salivary samples gathered again. Data analysis was performed using Kolmogorov-Smirnov, Wilcoxon, Kruskal Wallis tests with SPSS version 22 software.

Results

Baseline IL6 was higher in patients with severe ECC (p value = 0.007 and P = 0.001) but there was no statistically significant difference in baseline levels between first two groups. (p value = 0.059). After treatment only severe ECC group had statistically significant difference ofsalivary IL6 after treatment. (p value = 0.007).

Conclusion

Our findings show that salivary IL6 level could be a partial predictor of ECC lesions. Treatment in sever ECC caused statistically significant decrease in IL6 but IL6 change was not significantin mild group.

Language:
Persian
Published:
Journal of Isfahan Dental School, Volume:16 Issue: 1, 2020
Pages:
22 to 30
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