The effect of aerobic training with two types of normal and high cholesterol diet on antioxidant and cardiac oxidative stress in male rats

Obesity and cardiovascular disease are among the leading causes of mortality in the world. The aim of the present study was to determine the effect of aerobic training on some antioxidant and cardiac oxidative stress in male rats with two types of normal and cholesterol-rich diet.

40 male Wistar rats randomly divided into four groups of normal-control, normal-exercise, cholesterol-rich and cholesterol-exercises. The training groups performed 12 weeks (5 days a week) of endurance training. Prior to the beginning of the training period, the cholesterol-rich diet group rats were fed this diet for three months to induce hyperlipidemia and dietary intervention was administered until the end of the training period. 48 hours after the last training session, they were killed and then their heart tissues were separated and the experiments were performed.

Between groups analyses indicated a significant difference between groups consuming cholesterol and normal foods in the MDA (P = 0.001), TAC (P = 0.004) and glutathione (P = 0.013).

The results of this study showed that moderate-intensity aerobic activity improved oxidative stress indices and increased TAC in the hearts of mice with normal and high cholesterol diet.