THE EFFECT OF KETAMINE AND MIDAZOLAM IN REDUCING USE OF SEDATIVES FOLLOWING SPINAL ANESTHESIA IN ELECTIVE CESAREAN

Acute postoperative pain control after the cesarean section is important due to the importance of the primary contact between the mother and the infant. Two main groups of opioid and non-opioid analgesics are known for controlling pain after cesarean section. The use of opioids in a dose-dependent manner is accompanied by adverse maternal and neonatal complications. Therefore, in this study, we investigated the effect of two non-opioid drugs on the severity of pain after cesarean delivery as a clinical trial.

A total of 126 pregnant women enrolled in the study and they were randomly assigned to intervention (A, B) and control groups. In group A, ketamine was injected at 0.2 mg kg/mg and in group B (1 mg) midazolam was injected intravenously after the surgery. In the control group (C) normal saline was injected. Then, pain-related variables were recorded every 1, 2, 6, and 12 hours after the operation.

The results of our study showed that there is no significant difference in the use of these two drugs in control of pain after cesarean section, but there was a significant difference in the use of postoperative analgesia in ketamine group compared to the other two groups (p=0.01).

Based on the results of this study, the use of low dose venous ketamine after cesarean section can reduce the demand and use of postoperative analgesics.