Evaluation the effect of testosterone on the number of endothelial progenitor cells and amount of SDF-1α, PDGF, bFGF, and NO
Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background

Recent therapeutic advances in cardiovascular disease, thanks to the discovery of endothelial progenitor cells (EPCs). Stromal cell‑derived factor‑1α (SDF‑1α), platelet‑derived growth factor (PDGF), basic fibroblast growth factor (bFGF), and nitric oxide (NO) play a role in migration, homing, and differentiation of EPCs into mature endothelial cells. The incidence of cardiovascular disease is higher in men than in women. This fact suggests the influence of sex hormones on incidence of cardiovascular disease.

Methods

Twenty‑four female wistar rats weighing 160–180 g were randomly divided into four groups (N = 6): 1. sham‑treated by sesame oil, 2. ovariectomized (OVX)‑treated by sesame oil, 3. OVX‑treated by 10 µg/kg/day testosterone, and 4. OVX‑treated by 100 µg/kg/day testosterone. After 21 days, the animals were euthanized and blood samples were saved for determination of EPC count and serum levels of SDF‑1α, PDGF, bFGF, and NO production.

Results

High‑dose testosterone induced significant increase in EPC count in OVX rats (P ˂ 0.05). Also 100 µg/kg/day testosterone increased serum level of SDF‑1α more than OVX‑treated by 10 µg/kg/day testosterone (P ˂ 0.05). But 10 µg/kg/day testosterone increased significantly the serum level of PDGF >100 µg/kg/day testosterone‑treated group (P ˂ 0.05). The serum level of bFGF in sham‑treated by sesame oil was equal with its concentration in OVX‑treated by 100 µg/kg/day testosterone. And the serum concentration of NO production in testosterone‑treated groups were significantly less than other groups (P < 0.05).

Conclusions

This study suggests that testosterone might be effective on cardiovascular disease in females by increasing EPC count through SDF‑1α and PDGF mechanisms which are some of the vascular healing factors.

Language:
English
Published:
International Journal of Preventive Medicine, Volume:10 Issue: 12, Dec 2019
Page:
214
magiran.com/p2109506  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!