Hepatoprotective Activity of Royal Jelly on Mercuric Chloride–induced Damage Model in Rats

Mercuric chloride (MC) is the chemical composition of mercury,chlorine with manyside effects such as oxidative stress referring to mercury toxicity. Royal jelly (RJ) as a honey bee secretionhas antioxidant activities. This study was designed to evaluate the effects of RJ against the parametersof hepatic damage in male rats induced by MC toxicity. Materials,

In this study,48 malerats were randomly assigned into six groups: sham (saline),MC control (50mg,kg) groups,RJ groups(200mg,kg RJ for 1 day,200mg,kg RJ for 7 days,orally),MC + RJ groups (200mg,kg RJ orally+ 50mg,kg MC intraperitoneally for 1 day,and 200mg,kg RJ orally,50mg,kg MC intraperitoneallyfor 7 days). Griess technique was used for the determination of serum nitric oxide (NO) level. Aspartateaminotransferase (AST),alanine aminotransferase (ALT),and alkaline phosphatase (ALP) concentrationswere determined for liver functional disturbances value. In addition,thiobarbituric acid reactive species,antioxidant capacity,the diameter of hepatocytes,and the central hepatic vein (CHV) were investigated.

MC administration significantly increased the liver malondialdehyde (MDA),NO levels,themean diameter of CHV,hepatocyte,hepatic enzymes,and decreased tissue Ferric reducing antioxidantpower (FRAP) level compared to the sham group (P < 0.01). The RJ,RJ + MC in all treatmentssignificantly reduced the mean diameter of hepatocyte,CHV,hepatic enzymes,renal MDA,NOlevels,and increased tissue FRAP level compared to the MC control group (P < 0.01). It seems that RJadministration recovers the hepatic injury induced by MC in rats.