A Comparison on the Preventive Effect of 100 mg and 200 mg Oral Celecoxib on Shivering during and after Orthopedic Lower Extremity Surgery under the Spinal Anesthesia; A Randomized Controlled Clinical Trial Study

This study aimed to compare the anti-shivering effects of 100 mg and 200 mg oral celecoxib with control group undergoing orthopedic lower extremity surgeries under spinal anesthesia.

In a randomized double-blinded clinical trial study that was conducted at Ayatollah Kashani hospital in Isfahan, Iran, the patients undergoing elective orthopedic surgery of the lower extremity under spinal anesthesia with class 1 stage based on the American Society of Anesthesiologists (ASA) scale, were evaluated. The first group received placebo tablets, the second group received 100 mg oral celecoxib, and the third group received 200 mg oral celecoxib 3 hours prior to spinal anesthesia. Incidence and intensity of shivering was compared 10 minutes after the anesthesia, and every 15 minutes until the end of surgery in all three groups.

A significant difference was observed between the three groups at all periods of time (P < 0.05). The group receiving 200 mg celecoxib experienced the less shivering.

A dose of 200 mg oral celecoxib was reported to be more effective on shivering during and after the orthopedic lower extremity surgery in patients under spinal anesthesia as compared to 100 mg oral celecoxib and the control group.