Upper respiratory tract infection is one of the most common bacterial infections in humans and the second reason for the high administration of antibiotics. The upward trend of antibiotic resistance in bacterial pathogens is a worldwide challenge. The aim of the present study was to evaluate antibiotic resistance and biofilm formation of isolated bacteria from the upper respiratory tract of adult patients admitted to Shahid Bahonar Hospital in Kerman.
In this study, 70 sub cultured specimens of respiratory were received from laboratory of Shahid Bahonar Hospital in Kerman during three months . Examination and identification was done by routine biochemical tests. The disc diffusion antibiotic susceptibility test was also performed. Next, the percentage of cell surface hydrophobicity was determined. The isolates with highest and lowest hydrophobicity were selected to study biofilm formation on glass and polypropylene surfaces on static and shake conditions.
59 bacterial strains were isolated, respectively as %37.28 Staphylococcus aureus., %20.33 Klebsiella pneumonia, %16.94 pseudomonas aeruginosa, %6.77 Escherichia coli, %5.08 Streptococcus pneumonia and %3.38 Citrobacter spp., Serratia marcescen, Proteus mirabilis and Corynebacterium diphtheria. Maximum resistance was related to amoxicillin and all the strains were sensitive to gentamicin. The results of biofilm formation on the selected surfaces indicated biofilm formation increasing on propylene surfaces with shake condition.
According to the results, there is a direct relationship between antibiotic resistance and biofilm formation potential of isolates. An effective program can be developed by evaluating antibiotics susceptibility patterns and new therapeutic methods.
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