The effect of high intensity interval and continues training on cardiac stem cells function and myocardial regeneration capacity in male rats

have shown that exercise in many species leads to increase and improvement in cardiac function. It seems that variety of exercise increases the myocardial regeneration capacity by increasing the formation of new cardiomyocytes. The present study examines the effect of high intensity interval and continues training on cardiac stem cells function and myocardial regeneration capacity in male rats.

Twenty four Vistars male rats were divided into three groups HIIT,continuous and control. The protocol training were performed 5 sessions per week for 6 weeks.The heart rats were extracted and c-Kit and Ki67 values were analyzed by Immunohistochemistry and Nkx2.5 gene expression for cardiac stem cells was measured by Real Time-PCR. The data were analyzed by one way ANOVA (P≤0.05).

According to the results of this study, there was a significant increase in c-Kit cells in the HIIT (P≤0.00) and in the continuous group (P≤0.018) and Significant increase in positive Ki67 cells in the HIIT group (P≤0.00) and continuous group (P≤0.05. this increase was greater in the HIIT group. As well as a significant increase was observed in the expression of Nkx2.5 gene expression in the HIIT training group (P≤0.015) and in the continuing group (P≤0.03) which increased in the continuous group was grater.Conclusion It seems exercises training induce heart regeneration through increased stem cell proliferation, c-Kit differentiation and increases gene expression of Nkx2.5, which are the two primary causes of the early regeneration of the heart, that lead to production of new cells in heart tissue.