The necessity of urgent low-cost epidemiological studies with short duration about the role of BCG vaccine in preventing and controlling of COVID-19 in Iran
Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Objective (s)

Currently there is no effective treatment and vaccine for COVID-19. However, several studies showed that BCG vaccine has long lasting positive non-specific effects on several infectious and autoimmune diseases via ‘trained immunity’ mechanisms. Along with these exceptional properties of this vaccine, few ecological studies showed controversial association between the national vaccination policies and morbidity and mortality rate of COVID-19.

Methods

This Article, reviewed the immunological mechanisms that explain the enhanced immunity by BCG vaccine against COVID-19. Also the conducted ecological studies and the clinical trials that are being conducted by few countries were reviewed.

Results

Considering Iran’s national BCG vaccination program and the low evidence level of ecological studies, we suggest to Iranian universities of medical sciences to conduct low-cost but better epidemiological studies with short duration, using tuberculin test. These studies including case-control, historical cohort and survival analysis studies, which will assess the association between immunity against tuberculosis and COVID-19 and its prognosis. The results of these studies may guide researchers about the necessity of conducting clinical trials among high risk groups like hospital staffs.

Conclusion

Also as few studies have shown BCG vaccine has therapeutic effects on patients with type 1 diabetes and multiple sclerosis, conducting clinical trials among Iranian patients can measure not only the preventive effect of BCG vaccine against COVID-19 but also the therapeutic effect on these two chronic diseases also.

Language:
Persian
Published:
Pages:
139 to 144
magiran.com/p2117102  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!