Expression of Proviral Integration of Moloney Virus-2 (PIM2) Gene in Patients with Acute Myeloid Leukemia and its Clinical Significance
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Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:

Background: 

Despite extensive research in leukemia, intracellular events leading to prolongation of cell cycle and resistance to pro-apoptotic factors are still not clearly defined. In recent years, the search for such events led to focusing on an anti-apoptotic factor, PIM-2 (Proviral integration of Moloney virus-2). The aim of the present study was to assess the expression of PIM2 gene in patients with acute myeloid leukemia (AML) through quantitative real time polymerase chain reaction (QRT-PCR) and to correlate the results with clinical and laboratory findings of the patients as well as their response to the treatment.

Methods

80 patients with AML and control group were enrolled in the present study. QRT-PCR was used to study PIM2 gene expression.

Results

The mean expression level of PIM2 gene was significantly higher in AML patients (3.5941±7.7736) compared with the control group (0.5303±0.4014) (P=0.034). Its expression level was not different in terms of achieving remission. A positive correlation was observed between PIM2 gene expression and total leucocytic count (R=0.059, P=0.719), while there was a negative correlation between the gene expression and platelet count (R=-0.118, P=0.470). No significant correlation was found between PIM2 gene and patients’ response to treatment as (P=0.883) although it’s level was higher in patients who did not achieve complete remission (6.1±11.9) than patients who achieved complete remission (3.1±5.3).

Conclusion

The present study showed higher PIM2 expression level in AML patients than normal population. Also, its level was higher in patients who did not achieve complete remission.

Language:
English
Published:
Iranian Journal of Blood and Cancer, Volume:12 Issue: 1, Mar 2020
Pages:
6 to 11
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