Periodontitis can lead to a progressive destruction of periodontal tissues supporting the tooth. Developing biomaterials for tissue engineering has noticeably improved the existing treatment options. The present study investigated the gelatin-hydroxyapatite nanofibers as promising scaffolds for guided tissue regeneration (GTR).
The scaffolds were prepared through electro-spinning technique and then the physic-chemical properties and the cytotoxic effect (on dental derived mesenchymal stem cells) were assessed.
The nano-scaffolds were successfully prepared with mono-dispersed nano-scale diameter (102 ± 0.10 nm), negative surface charge (-20 ± 0.17 mV) and uniform network-shaped morphology. The treatment of the mesenchymal stem cells was derived from human dental pulp stem cells (hDPSC) with gelatin-hydroxyapatite nanofibers showed that the prepared scaffolds revealed a great proliferative effect. Besides, the applied method can be used to prepare fiber-based structures via other polymeric materials.
Incorporating different materials to decrease the degradation rate of the fibers can match with the speed of tissue regeneration. In this case, the prepared nanofibers can be applied as a membrane biomaterial.
GTR , Nano-scaffolds , Gelatin , Hydroxyapatite , Stem cell
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
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