Investigate the effect of alcoholic extract of bulbs of narcissus (Narcissus tazetta L.) on indexes of renal function

Narcissus flower has been rich in several different secondary metabolites including essential oils, trinoids, flanoids, phenolic compounds, alkaloids and has bioactive, pharmaceutical properties and is beloved in the perfume industry. This study aimed to investigate the effect of alcoholic extract of bulbs of narcissus on indexes of renal function.

In this study, 20 adult male rats were randomly divided into 3 experimental and one control group. Experimental groups received oral bulbs extract of 50, 100 and 150 mg/kg orally for 6 days. Blood samples were taken from all groups of mice on day 7 and renal function tests were performed. Data were analyzed by SPSS software version 21 and the results were presented as mean and standard deviation (Mean±SEM).

Total Proteins decreased significantly (P<0.01) at 100mg/kg Narcissus bulb extract. At the dose of 150 mg/kg of extract, total protein and albumin activity significantly decreased and creatinine significantly increased (P<0.05). Urea at 150 mg/kg concentration also showed a significant increase compared to the control group (P<0.01(. BUN did not change significantly at all doses of the extract compared to the control group.

Significant decrease in total protein and albumin, and significant increase in urea and creatinine, indicate toxicity at high doses of Narcissus bulb extract, which needs further histological studies.