A comprehensive Review of Analytical Methods for the Determination of Aceclofenac in Biological Fluids and Pharmaceutical Dosage Forms

Article Type:
Review Article (بدون رتبه معتبر)

Method development is the process to prove that the analytical methods employed to measure the concentration of active pharmaceutical drug in a particular compounded dosage form is acceptable. This must be validated to provide accurate data for regulatory submissions. Aceclofenac (ACE) is an analog of diclofenac, a non-steroidal anti-inflammatory drug (NSAIDs). The drug is used in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis ankylosing spondylitis, inflammation and relief of pain. The high importance of this class of drugs has prompted us to review the most important recent spectrophotometric methods for analyzing Aceclofenac in pure formulations, in various types of pharmaceutical dosage and in biological fluids published in the literature to date. They include spectrophotometry, high performance liquid chromatography, high performance thin layer chromatography, liquid chromatography-mass spectrometry, ultra high-performance liquid chromatography, mass spectrometry, and stability indicating methods.High sensitivity, speed, specificity and reproducibility make the use of these conventional methods for acetaminophen detection in routine analysis. They are time consuming, expensive and labour intensive though. Hence future research efforts are presumed to concentrate on developing novel methods to overcome these limitations.

Journal of Chemical Reviews, Volume:2 Issue: 3, Spring 2020
189 to 200
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