Biocompatibility Investigation of ‎Polyacrylonitrile/Fe (III) Metal-Organic ‎Framework Fibrous Scaffolds Treated ‎with Oxygen Plasma

Preparation of scaffolds with special characters for growing of different cells is considered as an important goal of tissue engineering. In this study, polyacrylonitrile (PAN) and its composites with different percentages of Fe (III) metal-organic frameworks (PAN/x%Fe-MOF) were treated with oxygen plasma. The surface chemistry of these compounds was studied using FT-IR spectroscopy. The morphology stability of the nanofibers after cell-scaffold adhesion was investigated by scanning electron microscopy (SEM). Metabolic activity and survival of endothelial cells cultured on scaffolds were evaluated by MTT method. In conclusion, the results of this study showed that PAN/x%Fe-MOF scaffolds, in particular oxygen plasma treated scaffolds, provide a suitable support for binding and proliferation of endothelial cells due to their high biocompatibility.