Effect of Endurance Training with Royal Jelly on CRP Gene Expression in Muscle Tissue of Rats with Alzheimer ’s Disease

Studies have shown that Alzheimer’s disease (AD) causes neuromuscular dysfunction by damaging different parts of the central nervous system and inflammation that can increase C-reactive protein (CRP) levels. Nevertheless, the beneficial effects of endurance training (ET) and royal jelly (RJ) on inflammation and reduction of CRP are not fully elucidated.

The aim of this research was to investigate the effect of ET with RJ on gene expression of CRP in muscle tissues of rats with AD.

In this experimental study, 24 rats with AD (8 mg/kg trimethyltin injection) were randomly divided into four groups of 1-ET, 2-ET + [RJ (100 mg/kg)], 3-RJ and 4-control. Also, six healthy rats were placed in the healthy control group to investigate the effects of AD induction on CRP gene expression. Endurance training groups performed endurance training with a speed of 15 - 20 m/min, 5 sessions per week for eight weeks.

Our findings showed ET and RJ significantly decreased CRP gene expression in muscle tissues of rats with AD (P = 0.001) as well as the interaction of ET and RJ was significant in reducing CRP gene expression in muscle tissues of rats with AD (P = 0.001).

It appears that ET and RJ have interactive effects on the reduction of CRP in muscle tissues of rats with AD.