Synthesis of Iron Nanocomposite Hydrogel and Study the Release of Doxorubicin Anticancer Drug

In this study, for the first time, the synthesis of iron nanocomposite hydrogel based on poly ((2-Dimethyl amino) ethylene methacrylate) grafted onto salep, as a biocompatible polymer, is reported. DMA monomers were grafted onto the salep backbone via initiation by APS, and at the same time, the crosslinking were occurred by using MBA. Factors affecting the water swelling during the hydrogel synthesis (monomer concentration, MBA concentration, APS concentration) were systematically optimized and the impact of various environmental conditions (different salt concentrations, pHs, mixed organic solvents, etc.) were examined. Furthermore, the doxorubicin release from iron hydrogel nanocomposite was studied. The results clearly show that the hydrogel nanocomposite can successfully release doxorubicin and the related delivery is pH-sensitive. To confirm the grafting of poly ((2-Dimethyl amino) ethylene methacrylate) onto the salep backbone, FT-IR spectra were used. The morphology of hydrogel was evaluated by SEM, and the size of iron nanoparticles in the matrix of hydrogel was measured by TEM and AFM (9-11 nm).