Determination of nucleation and induction time of crystallization of amoxicillin nanoparticles in the presence of surface active agents
Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Research subject

The use of nanoparticles, especially nano-antibiotics, increases their efficacy. More uniform release of antibiotics is one of the benefits of being nano. They can also be made using ointment or banderol to absorb through the skin to the infection, thereby reducing its side effects. Amoxicillin is one of the most widely used antibiotics in the world which can be prevented by increasing the use of other strong antibiotics if promoted as nanoparticles. Determining the mechanism of nanoparticle formation of this drug is an important factor for its commercial production.

Research approach

The purpose of this study was to determine the nucleation mechanism and time of induction of crystallization of amoxicillin nanoparticles in the presence of surface active agents ‘CTAB’ and ‘SDS’. Therefore, the effect of amoxicillin concentration and stabilizing concentration on the crystallization process was investigated. In this project, a combination of inductive-reactive crystallization was used. In this method, amoxicillin sodium was produced with sodium hydroxide, amoxicillin sodium, has a much higher solubility in water. Then, by adding hydrochloric acid, amoxicillin will be recovered and supersaturated. SEM and DLS analyzes were used to determine the properties of amoxicillin nanoparticles. All the experiments were repeated twice.

Main results

The results show that particles with a mean size of 50 nm were formed, and the particle stability was confirmed up to one week after formation. The results of the experiments show that the nucleation mechanism is the primary type with an average explanatory factor (R2) equal to 0.9887 and adding a stabilizing agent has no effect on the nucleation mechanism.

Language:
Persian
Published:
Journal of Applied researches of chemical - polymer, Volume:4 Issue: 1, 2020
Pages:
3 to 12
magiran.com/p2135349  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!