Effect of high intensity interval training (HIIT) on the gene expression of MMP-2, COL-III and myocardial function in type 2 diabetic rats

Regular exercise training the blood glucouse level fluctuates, modulates gene expression and reduse diabetic cardiomyopathy. The purpose of this study was to determine the effect of High intensity Interval training (HIIT) on the gene expression of MMP-2 , COL-III and myocardial function in type 2 diabetic rats.

This is an experimental study. For this purpose, 16 male diabetic rats were divided into 2 groups of numbers 8; High intensity Interval training (HIIT) and Control (C). Diabetes was induced in a pellet with a high-fat diet (30% fat and 25% fructose) for 24 weeks. After the last training session and afterwards recovery, subjects were sacrificed and their left ventricle was extracted. PCR-Real time was used to determine the expression of MMP-2 and COL-III genes and for the assessment of cardiac function was used M- mode echocardiography. to compare the groups independent t-test was used at alpha level of 0/05.genes expression of MMP-2 and COL-III in the training group respectively showed a significant decrease compared to the control group (P= 0.001) and (p=0.02). Weight did not significantly change in any of the groups. Glucose, insulin and insulin resistance index in the training group showed a significantly change compared to the control group.Ejection fraction(EF) and shortening fraction(SF) in training group respectively were sinificantly increase compared to the control group(P=0.001) and (P=0.01).It seems that,HIIT training possibely can with decreases the expression of MMP-2 and COL-III genes in diabetic cardiomyopathy and improves cardiac function.