Treatment of experimental vaginal candidiasis with ethanolic extract of propolis in goat

Candida albicans is a natural opportunistic flora on the skin and mucous membranes, growth in good conditions and causes clinical symptoms of candidiasis. Prophylactic and therapeutic administration of some antifungal agents has been caused drug resistance, so nowadays there is a need to introduce newer drugs for the treatment of candidiasis. In this study, 12 heads of 8 months old goats with a weight of 20 kg were used. After induction of vaginal candidiasis with Candida albicans (PTCC: 5027), animals were randomly divided into four groups: treated with ethanolic extract of propolis, treated with nystatin ointment, treated with glycerin and non-treated group. In this study, mucosal injuries occurred within 5 days. Ethanol extract of propolis during 5 days and nystatin within 7 days resolved the clinical signs of vaginal candidiasis. Mucosal injuries created in non-treated and glycerin-treated groups worsened over time by up to 3 weeks later. In the histopathological examination, the anti-inflammatory effects, the repair of sweat glands, sebaceous and hair follicles, and the removal of abscess from the dermis, in the treatment groups with ethanolic extract of propolis and nystatin, were significantly different from that of the non-treated and glycerin-treated groups. The results of this study showed that the ethanolic extract of propolis can repair vaginal candidiasis lesions in a shorter period compared to nystatin in goat.