The Effect of Berberis vulgaris (Barberry Fruit) on a Component of Metabolic Syndrome: A Randomized Clinical Trial
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Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background

The metabolic syndrome is associated with increased risks of cardiovascular diseases and diabetes mellitus.

Objectives

As alternative medicine emerged worldwide, this study aimed to evaluate the efficacy of Berberis vulgaris (barberry fruit) in the treatment of metabolic syndrome.

Methods

This is a randomized, placebo controlled, double-blind, trial with two treatment arms. A total of 60 patients with metabolic syndrome were randomly assigned to receive barberry or placebo tablets (one 550 mg tablets per day for 3 weeks). Total cholesterol, LDL, HDL, triglyceride, fasting blood sugar and hematocrit were measured before and after 21 days of treatment. Data were analyzed using Mann-Whitney U and paired t-test by SPSS (V.15) software. P-values < 0.05 were considered to be significant.

Results

In the barberry group, there was a significant decrease in systolic blood pressure (pre-treatment 123.1 ± 13.1 vs. post-treatment 117.7 ± 13.2, P-value = 0.04), waist circumference (pre-treatment 105.9 ± 7.5 vs. post-treatment105 ± 7.7, P-value = 0.04) and hematocrit (pre-treatment 45 ± 3.6 vs. post-treatment 43.5 ± 2.7, P-value = 0.004) but other parameters did not change significantly. Serum cholesterol was significantly reduced after intervention in the barberry group (-17 ± 61.1 vs. 23.6 ± 45, P-value = 0.02).

Conclusions

We observed a significant effect of barberry on systolic blood pressure and waist circumference. Further studies with larger samples are needed to longitudinally investigate the effect of metabolic syndrome.

Language:
English
Published:
Modern Care Journal, Volume:17 Issue: 2, Apr 2020
Page:
2
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