Comparison of Pregnancy Rate of Frozen Embryos by Two Methods: Long with GnRH Agonist and OCP with Estradiol Only

In the treatment of infertility, the management method of the luteal phase is controversial and there is no general agreement regarding the preferred protocol. The purpose of this study was to compare the pregnancy rate of frozen embryos in the Long method with the GnRH agonist and OCP with estradiol alone.

In clinical trial study a total of 128 IVF candidates were randomly assigned into two groups of 64 GnRH -OCP agonists (group A) and group receiving estradiol alone (group B). In group A, patients were treated 15 days after OCP for 12 days; GnRH agonists were also given for 14 days. In group B, estradiol valerate tablets 6 mg 2 times daily for 5 days were used for at least 10 days if normal endometrial thickness normal.

The study groups were similar in mean age, duration, type and cause of infertility (P> 0.05). The mean number of eggs taken, embryos formed, embryos transferred were similar in terms of number, motility, and morphology of the spermatozoa. Laboratory and clinical pregnancies in group A were 17.2% and 15.6%, respectively, in group B were 23.4% and 20.3%, respectively (P> 0.05). The rate of abortion and multiple pregnancies were 1.6% in group A and 3.1% in group B, respectively (P> 0.05).

Pregnancy rate of embryos frozen in Long method with GnRH agonist and OCP with estradiol was not significantly different only in pregnancy outcome.