Protective Effect of Royal Jelly on Methotrexate Infertility in Female Mice
Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:

Methotrexate is a chemotherapy drug that is widely used in neoplastic disorders and ectopic pregnancy. In previous research, the toxicity of methotrexate has been reported on the genital tract. The properties of Royal jelly such as impotence improvement, and antioxidant and anticancer function have been reported. Therefore, in the present research, the effect of Royal jelly on ovarian cells in NMRI female mice treated with methotrexate was investigated. In this study, 70 female mice were divided into: negative control (without injection), positive control (received 0.5 mg/kg methotrexate), sham, and three experimental groups (T1, T2, and T3 received methotrexate plus 25, 50 and 100 mg/kg Royal jelly). Intraperitoneal injection was performed for 8 days. After histological processing and staining, the ovarian tissue, primary, secondary and graafian follicles, yellow body, as well the number of generation was investigated. Data were analyzed by Tukey test and one way ANOVA. Results showed there was a significant decrease in the number of generation in positive control, but the number of generation in experimental groups returned to the initial state. Regarding the duration of fertility, there was a significant decrease in the fertility rate in T1 and T3 compared to positive control group. The results of estrogen hormone showed a significant decrease in positive control group compared to negative control and increased significantly in T1 and T2. The number of primary, secondary, and graafian follicles in T 2 and T3 showed a significant increase (P<0.001). According to the present study, it was found that with further investigations, the appropriate dose of Royal jelly could act as a protective agent against the side effects of methotrexate and improve fertility.

Language:
Persian
Published:
Journal of Animal Biology, Volume:12 Issue: 2, 2020
Pages:
13 to 22
magiran.com/p2142880  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!