Evaluation of gene network on tetracycline antibiotic resistance controlled by tetA and tetB genes using databases information

The process of antibiotic resistance is divided into two categories: intrinsic and acquired resistance. In intrinsic resistance, the bacteria show resistance due to their specific properties to one or all of the antibiotics. But acquired resistance is caused by molecular changes in susceptible bacteria and, eventually, it causes antibiotic-resistant bacteria to emerge. That could be due to chromosomal mutations, transposons, or transmissible plasmids. Numerous genes control the different mechanisms of bacterial resistance to antibiotics. The tetA and tetB genes are the major activating genes for tetracycline efflux mechanism, which decrease the concentration of tetracycline in bacterium. This study was performed to reconstruct the network of tetA and tetB genes using data and information in molecular databases. The reconstructed network clearly confirms that tetA and tetB genes have a direct role in tetracycline efflux. In association with other proteins, tetB, in addition to tetracycline efflux, plays a key role in the detoxification and antiport of a wide range of toxins, such as streptocycline and phenolic acids. Gene Anthology analysis showed that most of the genes involved in the tetracycline resistance process are membrane proteins and their molecular function is transporter.