The effect of the continuous aerobic and high-intensity interval training on IRS1 gene expression and its correlation with insulin resistance index of liver tissue in rats with type 2 diabetes mellitus

Physical activity has been recognized, as an effective way to prevent and treat diabetes. This study aimed to determine the effect of the continuous aerobic - versus high -intensity interval training on IRS1 gene expression and its correlation with insulin resistance index in liver tissue with type 2 diabetic rats.

In an experimental study, 24 male Wistar rats aged 6-5 weeks weighed 160 to 180 g. The rats were randomly divided into three groups of 8 controls, aerobic continuity, and severe periodicity. Each group performed their protocol five days a week for eight weeks. 24 hours after the last training session, blood samples were collected directly from heart of rats. The liver tissue was immediately extracted. Pearson correlation, one-way ANOVA and Tukey post hoc test were used to analyze the data.

The results of this research showed that both trainings had a significant effect on the expression of IRS1 gene in the liver of type 2 diabetes mellitus than in the control group (P=0.011), but no difference was observed in the two training groups (P=0.874). There was a significant correlation between IRS1 gene expression and insulin resistance index in the liver of type 2 diabetic rats after a HIIT and continuous exercise (P=-0.634). Increasing the IRS1 gene, reduced the insulin resistance index (r= -0.634, P=0.005).

It seems that both intensive and continuous aerobic exercises could be used to improve the indices studied in subjects with type 2 diabetes.