Herpes Zoster Ophthalmicus and Limbal Ischemia in A Patient with History of Ocular Graft‑Versus‑Host Disease

To report a rare complication of herpes zoster ophthalmicus (HZO).

A27‑year‑old man with a history of graft‑versus‑host disease (GVHD) presented with pain and redness in his left eye along with vesicular eruptions on the same side of the forehead from 40 days earlier.

In this case report, we present a case of HZO with severe limbal ischemia in a patient with ocular GVHD. The patient was administered with intensive topical preservative‑free lubrication, topical preservative‑free antibiotics, topical autologous serum 20%, topical non‑preservative steroid (methylprednisolone 1%), and oral valacyclovir 1 g twice daily. The patient underwent amniotic membrane patch surgery on bulbar conjunctiva and cornea, lateral tarsorrhaphy, and punctal occlusion for the left eye.

In this report, severe and extensive limbal ischemia caused by herpes zoster virus in an immunocompromised patient is reported.