Therapeutic effects of adipose-derived mesenchymal stem cells on gentamicin-induced renal failure

Considering the limitations of conventional therapeutic methods in renal failure, researchers are paying attention to the application of adipose-derived mesenchymal stem cells (AD-MSCs) and their protective effects against acute renal failure. This study aims to assess the therapeutic effects of AD-MSCs in gentamicin-induced renal failure in rats.

In this study, 40 male Wistar rats were studied in control, sham, gentamicin treated with and without receiving AD-MSCs. After 10 days, blood samples were collected and hemodynamic parameters, malondialdehyde and ferric reducing antioxidant power (FRAP) measured in the right and left kidneys underwent histologic examination.

Gentamicin administration significantly increased plasma creatinine, blood urea nitrogen, oxidative stress parameters and histologic damages; while significantly reduced FRAP in the gentamicin-receiving group in comparison with the sham group. AD-MSCs treatment significantly improved renal function parameters, oxidative stress and histologic damages in comparison with the gentamicin receiving group.

Intravenous injection of AD-MSCs in gentamicin-induced renal failure improved renal function, oxidative stress parameters and histologic damages.