Evaluation of Antifungal Effects of Prangos ferulace and Plantago major L Plants Against Fluconazole-resistant Candida albicans Species in Extracorporeal Conditions
Message:
Abstract:
Introduction

Medicinal plants can be effective in treating diseases due to having various antifungal compounds. The aim of this study was to evaluate the antifungal effects of Prangos ferulace and Plantago majorL against fluconazole-resistant Candida albicans in extracorporeal conditions.

Materials and Methods

This study was experimental. Prangos ferulace and Plantago majorL plants were prepared from stores in Yasuj, Iran, in the spring and then scientifically approved by the Zardband Pharmaceutical Company in Yasuj. The extract was extracted after sending the plants to the Research Center for Medicinal Plants of Yasuj University of Medical Sciences. In order to prepare the aqueous extract of the plants, 3 g of plant powder was added to 30 ml of distilled water and placed on a shaker (Behdad, Tehran, Iran) for 24 h. The strain used in the present study was Candida albicans ATCC 10231, which was prepared by Shiraz University of Medical Sciences, Shiraz, Iran. In the present study, the alcoholic extracts of Prangos ferulace and Plantago major L were used at the concentrations of 7.5, 15, and 30 mg/ml. The non-growth halo diameter (in millimeters) was measured using the standard paper disc diffusion method. The minimum inhibitory concentrations (MICs) required to inhibit the growth of 90% and 50% of organisms were also evaluated. Finally, the number of living cells was counted, and the data were analyzed using ANOVA test in SPSS software (version 23).

Results

The results showed that at a concentration of 30 mg/ml, the maximum diameters of the non-growth halo were 15.3 mm for Prangos ferulace and 12.4 mm for Plantago major L. Regarding the MIC value, the MIC50 and MIC90 were respectively obtained as 19 and 38 μg/ml for Prangos ferulace and 14 and 29 μg/ml for Plantago major L (p < 0.05). Considering the live cell count, the lowest number of live cells was formed at a dilution of 10. The mean value of this variable was obtained as 7.3 and 4.2 CFU/ml for Prangos ferulace and Plantago major, respectively.

Conclusion

Prangos ferulace and Plantago major L. prevented the activity of Candida albicans due to their effective medicinal compounds.

Article Type:
Research/Original Article
Language:
Persian
Published:
Pages:
44 - 52
magiran.com/p2168767  
برخی از خدمات از جمله دانلود متن مقالات تنها به مشترکان مگیران ارایه می‌گردد. شما می‌توانید به یکی از روش‌های زیر مشترک شوید:
اشتراک شخصی
در سایت عضو شوید و هزینه اشتراک یک‌ساله سایت به مبلغ 400,000ريال را پرداخت کنید. همزمان با برقراری دوره اشتراک بسته دانلود 100 مطلب نیز برای شما فعال خواهد شد!
پرداخت با کارتهای اعتباری بین المللی از طریق PayPal امکانپذیر است.
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی همه کاربران به متن مطالب خریداری نمایند!
توجه!
  • دسترسی به متن مقالات این پایگاه در قالب ارایه خدمات کتابخانه دیجیتال و با دریافت حق عضویت صورت می‌گیرد و مگیران بهایی برای هر مقاله تعیین نکرده و وجهی بابت آن دریافت نمی‌کند.
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.