The aim of this study was to compare the anti-proliferative,apoptotic effects of hydroalcoholic extracts of different herbal medicines (Achillea wilhelmsii,Silybum marianumseed,Echinacea purpurea,Adiantum capillus-venerisand apricot kernel) against breast cancer cells (Mcf-7).Material,
For this purpose,the plants were dried,milled,then,soaked in 70% ethanol for 72 hours,their extracts were extracted using a rotary evaporator.Different concentrations of herbal extracts (12.5,25,50,100 μg,ml) were added to the cancer cell culture medium,their cytotoxicity,apoptotic effects were investigated after 24h by MTT assay,acridine orange - ethidium bromide staining,respectively.Data was analyzed by SPSS software at the significant level of 5%.
Addition of the highestconcentration of all extracts to the culture mediumshowed the most significant anti-proliferative,apoptotic effects (P<0.05) compared to other concentrations of the same extracts.Also,among the high concentrations (100μg,ml),the highest cell cytotoxicity effects were related to the extracts of Echinacea purpureaand Adiantum capillus-veneris (P<0.05).
The results of this study indicated that the addition of Echinacea purpurea,Adiantum capillus-venerisextractsto the cell culturesin high concentrationshad the most significant anti proliferative,apoptotic effects on breast cancer cells in comparison with other plant extractsand concentrations.
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