The metabolically effects of the short term endurance training among rat model of 6-hydroxydopamine Parkinson’s disease

Parkinson’s disease (PD) is known to affects the Body weight. These changes are due to multifactorial different mechanisms and training can affect on these disorders. In this study, is assessed the effect of short term endurance training on weight changes and mRNA expression of Sirtuin 1 (SIRT-1) and Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in rats model of 6-OHDA.

In this empirical study, Parkinson’s rats were made using stereotaxic device and by 8𝜇g injection of 6-hydroxydopamine (6-OHDA) into the Medial Forebrain Bundle (MFB). Thirty two male Wistar rats are assessed in experimental groups including: 1. Saline (Sham), 2. Saline+training, 3. 6-OHDA and 4. 6-OHDA+training (n=8). Training groups 2 weeks after the surgery started 14 consecutive days treadmill running. One month after the surgery, the rat’s weight were analyzed and using of Real Time-PCR method mRNA expression levels of the metabolically and mitochondrial factors of SIRT-1 and PGC-1α, in the striatum of rats, were measured through one way ANOVA.

The 6-OHDA resulted in weight loss, significant decrease in expression of PGC-1α mRNA and a compensatory increase in SIRT-1 mRNA. However, endurance training in 6-OHDA+training group reduces these disorders, and increases mRNAs up to normal level in the Sham group (p≤0/05).

The endurance training can reduce disorder in body weight and metabolic factors in Parkinson’s disease.